OVEREXPRESSION OF ADENYLYL CYCLASE ENCODED BY THE MYCOBACTERIUM TUBERCULOSIS RV2212 GENE CONFERS IMPROVED FITNESS, ACCELERATED RECOVERY FROM DORMANCY AND ENHANCED VIRULENCE IN MICE

Earlier we demonstrated that the adenylyl cyclase (AC) encoded by the MSMEG_4279 gene plays a key role in the resuscitation and growth of dormant Mycobacterium smegmatis and that overexpression of this gene leads to an increase in intracellular cAMP concentration and prevents the transition of M.smegmatis from active growth to dormancy in an extend

Chrysanthemum indicum var.aromaticum (CIA) is an endemic plant that occurs only in the high mountain areas of the Shennongjia Forest District in China.The whole plant, in particular the flowers of CIA, have intense fragrance, making it a novel resource plant for agricultural, medicinal, and industrial applications.However, the volatile metabolite e

Introduction: Hereditary Multiple Exostoses (HME) is an inherited genetic skeletal disorder of enchondral bone.It is an autosomal dominant disorder affecting juxtaepiphyseal region of the long bones and includes multiple exostoses.The treatment of HME is mainly surgical, while the medical approach is still in evolving phase.Surgery is needed only i

Variation in coat color among equids has attracted significant interest in genetics and breeding research.The range of colors is primarily determined by the type, concentration, and distribution of melanin pigments, with the balance between eumelanin and pheomelanin influenced by numerous genetic factors.Advances in genomic and sequencing technolog

Nadaa B Ali,1 Stephen R Pelletier,2 Helen M Shields1 1Department of Medicine, Brigham and Women’s Hospital, 2Center for Evaluation, Harvard Medical School, Boston, MA, USA Purpose: Medical students are expected to develop excellent communication skills.The purpose of our study was to create an innovative communication skills exercise using re